Prof Matthias Lütolf

In this in-depth interview, Matthias Lütolf looks back on the scientific milestones that have shaped his career, both in academia and in industry, from his pioneering work on organoids at the École Polytechnique Fédérale de Lausanne to his role as head of the Translational Bioengineering Laboratory at Roche. He explains how engineering principles, automation and AI are transforming organoids into predictive models relevant to humans in the context of drug discovery, whilst addressing the key scientific, industrial and regulatory challenges that still stand in the way of replacing animal testing and accelerating translational medicine.

Roche Institute of Human Biology (IHB) ©IHB Roche